Synthesis and anticancer activity of various 3'-deoxy pyrimidine nucleoside analogs, and crystal structure of 1-(3-deoxy-. beta.-D-threo-pentofuranosyl) cytosine

…, JH Yang, MC Liu, ZY Shen, YC Cheng…

Index: Lin, Tai-Shun; Yang, Jin-Hua; Liu, Mao-Chin; Shen, Zhi-Yi; Cheng, Yung-Chi; et al. Journal of Medicinal Chemistry, 1991 ,  vol. 34,  # 2  p. 693 - 701

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Citation Number: 35

Abstract

Various 3'-deoxy pyrimidine nucleoside analogues have been synthesized for evaluation as potential anticancer and antiviral agents. Among these compounds, l-(3-deoxy-/3-D-threo- pentofuranosyl) cytosine (10, 3'-deoxy-ara-C) and 3 '-deoxycytidine (22) had significant anticancer activity against CCRF-CEM, L1210, P388, and S-180 cancer cell lines in vitro, producing ED, values of 2, 10, 5, and 34 pM, respectively, for 3'-deoxy-ara-C (10); and 25, ...