Since its introduction by Stork and Hudrlik, 1 and Corey and Venkateswarlu, 2 the tert- butyldimethylsilyl (TBDMS) group has become the most popular and useful hydroxy protecting group in chemical synthesis. 3, 4 One of the greatest challenges in this field is the selective deprotection of primary TBDMS groups in the presence of their secondary counterparts, a procedure which has considerable utility for synthetic chemists. 5 During a ...
