A new photolabile protecting group (PPG) for carboxylic acids and amines has been developed based on the rapid singlet state photodecarboxylation of xanthone acetic acids with several features that are superior to many other systems. We demonstrate that the “xanthonate” PPG can photorelease carboxylic acids and amines (via the carbamates) quantitatively in neutral phosphate buffer solution with a remarkable “uncaging cross ...
