Quadruplex ligands have potential as anti-cancer agents 10 that act by interference with telomere maintenance 11 or by alteration of oncogene expression levels. 5,12 The modification of flat, aromatic molecules has led to G-quadruplex ligands that bind by a mode presumed to involve stacking with the terminal G-tetrad(s). 13 However, the G-tetrads are common to all quadruplexes, making discrimination between quadruplexes challenging. Given the ...
