Design of antineoplastic agents based on the “2-phenylnaphthalene-type” structural pattern. 4. Synthesis and biological activity of 2-chloro-3-(substituted phenoxy)-1, …

HX Chang, TC Chou, N Savaraj, LF Liu…

Index: Chang, He-Xi; Chou, Ting-Chao; Savaraj, Niramol; Liu, Leroy F.; Yu, Chiang; Cheng Journal of Medicinal Chemistry, 1999 , vol. 42, # 3 p. 405 - 408

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Citation Number: 40

Abstract

The intermediate in the preparation of 1, 3, 7, 10-tetrahydroxybenzo [b] naphtho [2, 3-d] furan- 6, 11-dione (2), 2-chloro-5, 8-dimethoxy-3-(3, 5-dimethoxyphenoxy)-1, 4-naphthoquinone (8h), and corresponding hydroxyl, methoxyl, and acetoxyl analogues was found to possess interesting inhibitory activities in a number of cytotoxic test systems. Activities were also noticed in some 5, 8-dihydroxy-1, 4-naphthoquinone derivatives. A structure-activity ...