Synthesis and cytotoxic activities of 4, 5-diarylisoxazoles

…, CY Cheng, YC Tsai, CW Chu, YH Din, YP Chau…

Index: Sun, Chang-Ming; Lin, Lee-Gin; Yu, Hsi-Jung; Cheng, Chih-Yu; Tsai, Ya-Chuan; Chu, Chi-Wei; Din, Yi-Hui; Chau, Yat-Pang; Don, Ming-Jaw Bioorganic and Medicinal Chemistry Letters, 2007 , vol. 17, # 4 p. 1078 - 1081

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Citation Number: 42

Abstract

A series of 4, 5-diarylisoxazoles related to combretastatin A-4 (CA-4) were synthesized and evaluated for cytotoxicity against three human cancer cell lines. Among them, compound 6e showed better cytotoxic activity than CA-4 in HeLa and HepG2 cell lines assayed with IC50 value as low as 0.022 and 0.065 nM, respectively.

~51%

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