Tetrahedron letters

Lipase-catalyzed enantioselective hydrolysis of N-acyloxymethyl groups in organic solvent: syntheses of chiral 5, 5-disubstituted 1-methylbarbiturates

M Murata, K Achiwa

Index: Murata, Masakazu; Achiwa, Kazuo Tetrahedron Letters, 1991 , vol. 32, # 46 p. 6763 - 6766

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Citation Number: 24

Abstract

Abstract: Chid 5, 5,-disubstituted~-acyloxymethylb~ biturates have been obtains in 40-99% optical yields by lipase-catalyzed hydrolyses of 5, S-disubstituted bisacyfoxymethylbarbiturates in HzO-saturated diisopropyl ether, These chiral barbiturates were readily converted into the corresponding chiral N-methylbarbiturates such as (I?)-(-)- mephobarbital and (S)-(+)-hexobarbital.