Bioorganic & medicinal chemistry

The anticonvulsant activities of functionalized N-benzyl 2-acetamidoacetamides. The importance of the 2-acetamido substituent

D Choi, JP Stables, H Kohn

Index: Choi, Daeock; Stables, James P.; Kohn, Harold Bioorganic and Medicinal Chemistry, 1996 , vol. 4, # 12 p. 2105 - 2114

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Citation Number: 24

Abstract

Recent studies have demonstrated that substituted N-benzyl 2-acetamidoacetamides provide significant protection against maximal electroshock (MES)-induced seizures in mice and rats. In this study, we investigated whether the 2-acetamido moiety was necessary for anticonvulsant activity. Ten derivatives of the known anticonvulsant, N-benzyl 2-acetamido-2- phenylacetamide were prepared in which the 2-acetamido group was replaced by ...