We have developed a highly efficient method for the site-specific attachment of biophysical probes to unprotected peptides after chemical synthesis. This methodology takes advantage of the selective reactivity of an N-methylaminooxy amino acid that is appropriately protected for direct incorporation during solid-phase peptide synthesis. The functional N- methylaminooxy group is unmasked using normal peptide cleavage conditions and is ...
![2-[[2-[(2-chlorophenyl)methoxy]-2-oxoethyl]amino]oxyacetic acid Structure](https://image.chemsrc.com/caspic/084/271795-05-2.png)
