Bioorganic & medicinal chemistry letters

A prodrug system for hydroxylamines based on esterase catalysis

A Conejo-Garcia, CJ Schofield

Index: Conejo-Garcia, Ana; Schofield, Christopher J. Bioorganic and Medicinal Chemistry Letters, 2005 , vol. 15, # 18 p. 4004 - 4009

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Citation Number: 13

Abstract

The synthesis and reactivity of hydroxy hydroxamates as models for a prodrug form of hydroxylamine are described. γ-Hydroxy hydroxamates were found to enable hydroxylamine release via lactonisation. Hydroxamates were found to undergo esterase catalysed hydrolysis.

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