Summary 1. The semi-micro synthesis of crystalline 2, 3-estracatechol (2-hydroxyestrone) via the corresponding nitro, amino and diazonium compounds has been reported. The final product and its intermediates have been characterized by the preparation of derivatives. The results of estrogenic assays have been presented. The lack of estrogenic activity of 2, 3- estracatechol and its 3-methyl ether is in harmony with the view that hydroxylation may be ...
