Tetrahedron

One-pot reductive amination of aldehydes and ketones with α-picoline-borane in methanol, in water, and in neat conditions

S Sato, T Sakamoto, E Miyazawa, Y Kikugawa

Index: Sato, Shinya; Sakamoto, Takeshi; Miyazawa, Etsuko; Kikugawa, Yasuo Tetrahedron, 2004 , vol. 60, # 36 p. 7899 - 7906

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Citation Number: 178

Abstract

A one-pot reductive amination of aldehydes and ketones with amines using α-picoline- borane as a reducing agent is described. The reaction has been carried out in MeOH, in H2O, and in neat conditions in the presence of small amounts of AcOH. This is a highly efficient and mild procedure that is applicable for a wide variety of substrates. In particular, this is the first successful demonstration that this type of reaction can be carried out in ...