Orthogonal approaches to the simultaneous and cascade functionalization of macromolecules using click chemistry

M Malkoch, RJ Thibault, E Drockenmuller…

Index: Malkoch, Michael; Thibault, Raymond J.; Drockenmuller, Eric; Messerschmidt, Martin; Voit, Brigitte; Russell, Thomas P.; Hawker, Craig J. Journal of the American Chemical Society, 2005 , vol. 127, # 42 p. 14942 - 14949

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Citation Number: 315

Abstract

The development of selective chemistries that are orthogonal to the diverse array of functional groups present in many polymeric systems is becoming an important tool for the synthesis and use of macromolecules in fields ranging from biomedical devices to nanotechnology. By combining copper-catalyzed cycloaddition chemistry with other synthetic transformations such as esterification, amidation, etc., highly efficient and ...