Tetrahedron

A mild high yielding synthesis of oxazole-4-carboxylate derivatives

…, EMS Castanheira, LS Monteiro, G Pereira, H Vilaça

Index: Ferreira, Paula M.T.; Castanheira, Elisabete M.S.; Monteiro, Luis S.; Pereira, Goreti; Vilaa, Helena Tetrahedron, 2010 , vol. 66, # 45 p. 8672 - 8680

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Citation Number: 23

Abstract

Several 2, 5-disubstituted oxazole-4-carboxylates were prepared in high yields from the methyl esters of N-acyl-β-halodehydroaminobutyric acid derivatives by treatment with a 2% solution of DBU in acetonitrile. The scope of this reaction was investigated and it was found that dehydrodipeptides having a β-bromodehydroaminobutyric acid residue gave the corresponding oxazoles in good yields. The photophysical properties of some of the ...