Tetrahedron letters

Marschalk reaction approach for a simple synthesis of (±) 4-demethoxydaunomycinone

AB Argade, AR Mehendale, NR Ayyangar

Index: Argade; Mehendale; Ayyanger Tetrahedron Letters, 1986 , vol. 27, # 30 p. 3529 - 3532

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Citation Number: 3

Abstract

Abstract Marschalk reaction of leucoquinizarin 2 with levulinic (oxo-ketal) aldehyde 3 gave 2- (4′-oxo-n-pentane)-quinizarin 4b, which on formylation followed by second Marschalk reaction led to (±)-4-demethoxy-7, 9-dideoxydaunomycinone 6 which is further exploited for