Abstract Octahydro-7-phenylpyrazino [2, 1-b][3] benzazepine (1a) was prepared from 1- methyl-3-phenylmethylpiperazine 5a by reaction with styrene oxide followed by sulfuric acid cyclization of the resulting alcohol 6a. The diastereomeric mixture 1a was further separated into the diastereomers 1a′ and 1a ″. Similarly 1-methyl-3-(3-chloro-4-methoxyphenyl) piperazine was reacted with styrene oxide to yield 6c which on cyclization with 1.5 ...