A one step synthesis of 1-alkylpyrazolo [5, 4-d] pyrimidines

…, L Campbell, W Liao, Q Meng, Z Peng, X Wang…

Index: Boyd, Scott; Campbell, Leonie; Liao, Wensheng; Meng, Qinghong; Peng, Zuozhong; Wang, Xiaoping; Waring, Michael J. Tetrahedron Letters, 2008 , vol. 49, # 52 p. 7395 - 7397

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Citation Number: 12

Abstract

A new synthesis of 1-alkylpyrazolo [5, 4-d] pyrimidines is described. The reaction of 4, 6- dichloropyrimidine-5-carbaldehyde with various substituted hydrazines provides such compounds in a single step from commercially available starting materials. This method has advantages over methods currently described in the literature for the construction of such ring systems.

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