New saccharin derivatives as tyrosinase inhibitors

…, D Demir, F Sonmez, M Kucukislamoglu

Index: Gener, Nahit; Demir, Dudu; Sonmez, Fatih; Kucukislamoglu, Mustafa Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 9 p. 2811 - 2821

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Citation Number: 23

Abstract

A newly series of 6-(phenylurenyl/thiourenyl) saccharin (6a–y) derivatives were synthesized and their inhibitory effects on the diphenolase activity of banana tyrosinase were evaluated. A 70-fold purification of the enzyme with 6.85% yield was achieved by using a Sepharose 4B-l-tyrosine-p-amino benzoic acid affinity column. The result showed that all the synthesized compounds inhibited the tyrosinase enzyme activity. Among the compounds ...