Facile Catalyst-Free Allylation of Isatins Under Mild Conditions in Dimethylformamide

…, QC Huang, FY Wang, XY Xu, LX Wang

Index: Jia, Li-Na; Peng, Lin; Wang, Liang-Liang; Bai, Jian-Fei; Fu, Ji-Ya; Huang, Qing-Chun; Wang, Fei-Ying; Xu, Xiao-Ying; Wang, Li-Xin Letters in Organic Chemistry, 2011 , vol. 8, # 5 p. 352 - 357

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Abstract

The catalyst-free allylation of isatins with allyltrichlorosilane was performed smoothly in DMF under mild conditions and moderate to excellent yields (60%-94%) were obtained. This protocol provided a new and efficient approach for the preparation of 3-allyl-3-hydroxy-2- oxindoles.