Crenulacetal C, a Marine Diterpene, and Its Synthetic Mimics Inhibiting Polydora websterii, a Harmful Lugworm Damaging Pearl Cultivation.

…, T Ooi, T KUSUMI, S AKERA, M MURAMATSU…

Index: Takikawa, Mami; Uno, Kiyoko; Ooi, Takashi; Kusumi, Takenori; Akera, Shusaku; Muramatsu, Morimitsu; Mega, Hirohiko; Horita, Chie Chemical and Pharmaceutical Bulletin, 1998 , vol. 46, # 3 p. 462 - 466

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Citation Number: 9

Abstract

Polydora websterii, a harmful lugworm that has serious adverse effects on pearl oyster cultivation, was inhibited by a marine diterpene, crenulacetal C, isolated from the brown alga Dictyota dichotoma, Based on consideration of the activity-structure relationship, several synthetic compounds having an aromatic moiety with a hydroxyalkyl chain were prepared. Bioassay using larvae of Polydora websterii as well as pearl oysters (Pinctada fucata ...