Novel Spiroheterocycles by Aziridination of α??Methylene?螃摸?and?螃宁?lactams

MA Loreto, A Migliorini, PA Tardella…

Index: Loreto, M. Antonietta; Migliorini, Antonella; Tardella, P. Antonio; Gambacorta, Augusto European Journal of Organic Chemistry, 2007 , # 14 p. 2365 - 2371

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Citation Number: 13

Abstract

Abstract New potentially bioactive α-spiroaziridino-γ-and-δ-lactams have been prepared by treatment of α-methylene-γ-and-δ-lactams with ethyl N-{[(4-nitrophenyl) sulfonyl] oxy} carbamate (NsONHCO 2 Et) in the presence of CaO. These compounds, through reductive aziridine ring opening, can be intermediates for the synthesis of α-and β-aminolactams, which are useful as conformational constraints in peptides. The above procedure has ...