Highly Efficient Cyclization of o??Iodobenzoates with Aldehydes Catalyzed by Cobalt Bidentate Phosphine Complexes: A Novel Entry to Chiral Phthalides

HT Chang, M Jeganmohan…

Index: Chang, Hong-Tai; Jeganmohan, Masilamani; Cheng, Chien-Hong Chemistry - A European Journal, 2007 , vol. 13, # 15 p. 4356 - 4363

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Citation Number: 50

Abstract

Abstract Methyl 2-iodobenzoates 1 a–c undergo cyclization reactions with various aromatic aldehydes 2 a–m (RC 6 H 4 CHO: R= H 2 a, 4-CH 3 2 b, 4-tBu 2 c, 4-OMe 2 d, 3-OMe 2 e, 4- Cl 2 f, 4-CF 3 2 g, 4-CN 2 h, 4-Ph 2 i; benzo [d][1, 3] dioxole-5-carbaldehyde (2 j), 1- napthaldehyde (2 k), benzofuran-2-carbaldehyde (2 l), and isonicotinaldehyde (2 m)) in the presence of [CoI 2 (dppe)](dppe= 1, 2-bis (diphenylphosphino) ethane) and Zn powder in ...