e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Quinoline-2, 4-dicarboxylic acids: synthesis and evaluation as inhibitors of the glutamate vesicular transport system
CN Carrigan, CS Esslinger, RD Bartlett…
Index: Carrigan, Christina N.; Esslinger, C. Sean; Bartlett, Richard D.; Bridges, Richard J.; Thompson, Charles M. Bioorganic and Medicinal Chemistry Letters, 1999 , vol. 9, # 17 p. 2607 - 2612
Twenty-six quinoline-2, 4-dicarboxylic acids (QDC's) were synthesized by a modified Doebner-von Miller pathway and tested as inhibitors against the glutamate vesicular transport (GVT) protein. The QDC's were active as inhibitors with the most potent QDC's found to contain halogens at the 6-/8-position, a hydroxyl at the 8-position, or a tethered aromatic moiety at the 6-or 7-position of the quinoline.
