Synthesis of Functionalized Isoquinolin??1 (2H)??ones by Copper??Catalyzed α??Arylation of Ketones with 2??Halobenzamides

Y Shi, X Zhu, H Mao, H Hu, C Zhu…

Index: Shi, Yan; Zhu, Xuebin; Mao, Haibin; Hu, Hongwen; Zhu, Chengjian; Cheng, Yixiang Chemistry - A European Journal, 2013 , vol. 19, # 35 p. 11553 - 11557

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Abstract

Owing to their wide range of biological activities, unusual pharmacological properties and their ubiquity in many natural products, heterocyclic ring systems are an important area of interest for chemists.[1] As a result the search for novel approaches toward their construction continues to be a major topic of research in organic chemistry.[2] Recently, transition-metal- catalyzed α-arylation of carbonyl and related compounds has emerged as an ...