Amino Acid Esters and Amides for Reductive Amination of Mucochloric Acid: Synthesis of Novel γ??Lactams, Short Peptides and Antiseizure Agent Levetiracetam ( …

K Das Sarma, J Zhang, Y Huang…

Index: Das Sarma, Koushik; Zhang, Ji; Huang, Yun; Davidson, James G. European Journal of Organic Chemistry, 2006 , # 16 p. 3730 - 3737

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Citation Number: 23

Abstract

Abstract A simple methodology utilizing mucochloric acid anddifferent α-and β-amino acid esters, amides and shortpeptides for the synthesis of novel γ-lactam and γ-lactam-based short peptides was developed. The synthesis of an antiseizure agent, Levetiracetam (Keppra®) was demonstrated.(© Wiley-VCH Verlag GmbH & Co. KGaA, 69451 Weinheim, Germany, 2006)