Novel S-substituted aminoalkylamino ethanethiols as potential antidotes against sulfur mustard toxicity

…, AS Kulkarni, R Vijayaraghvan, P Kumar…

Index: Pathak, Uma; Raza, Syed K.; Kulkarni; Vijayaraghvan, Rajagopalan; Kumar, Pravin; Jaiswal, Devendra K. Journal of Medicinal Chemistry, 2004 , vol. 47, # 15 p. 3817 - 3822

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Citation Number: 22

Abstract

Sulfur mustard (SM) is a highly toxic chemical warfare agent. A satisfactory treatment regimen is not yet available for this toxicant. In a search for an effective antidote against SM, a series of novel S-2 (ω-aminoalkylamino) ethyl alkyl/aryl thioethers [H2N (CH2) n NHCH2CH2SR], where R= alky, alicyclic, aryl, and heterocyclic substituents, have been designed and synthesized as candidate antidotes against SM toxicity. These compounds ...