Structure–activity relationships of new cyanothiophene inhibitors of the essential peptidoglycan biosynthesis enzyme MurF

…, C Contreras-Martel, A Dessen, AJ O'Neill…

Index: Hrast, Martina; Turk, Samo; Sosic, Izidor; Knez, Damijan; Randall, Christopher P.; Barreteau, Helene; Contreras-Martel, Carlos; Dessen, Andrea; O'Neill, Alex J.; Mengin-Lecreulx, Dominique; Blanot, Didier; Gobec, Stanislav European Journal of Medicinal Chemistry, 2013 , vol. 66, p. 32 - 45

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Citation Number: 12

Abstract

Abstract Peptidoglycan is an essential component of the bacterial cell wall, and enzymes involved in its biosynthesis represent validated targets for antibacterial drug discovery. MurF catalyzes the final intracellular peptidoglycan biosynthesis step: the addition of d-Ala-d-Ala to the nucleotide precursor UDP-MurNAc-l-Ala-γ-d-Glu-meso-DAP (or l-Lys). As MurF has no human counterpart, it represents an attractive target for the development of new ...