Synthesis with pyridine N-oxides. III. Synthesis of 2-arylisoxazolo [2, 3-a] pyridinium bromides via acid catalyzed rearrangements of 1-aryl-2-(2-pyridinyl) ethanone N- …

DT Connor, PA Young…

Index: Connor,D.T. et al. Journal of Organic Chemistry, 1977 , vol. 42, p. 1364 - 1366

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Citation Number: 6

Abstract

2-Methylquinoxaline-3-carboxylic Acid 1-Oxide (17). Methyl 2-methyl-3- quinoxalinecarboxylate 1-oxide (5.00 g, 23.0 mmol) was suspended in aqueous 0.5 M sodium hydroxide solution (50 mL). All starting material went into solution within 10 min, and a white precipitate formed upon addition of aqueous 0.5 M hydrochloric acid solution (50 mL). The solid was collected and recrystallized from water to give 4.00 g (81%) of 17: 4b ...