Synthesis of 2-(Pyridin-3-yl)-1-azabicyclo [3.2. 2] nonane, 2-(Pyridin-3-yl)-1-azabicyclo [2.2. 2] octane, and 2-(Pyridin-3-yl)-1-azabicyclo [3.2. 1] octane, a Class of …

…, CH Miller, P Tahiri, PA Crooks, N Deo…

Index: Bhatti, Balwinder S.; Strachan, Jon-Paul; Breining, Scott R.; Miller, Craig H.; Tahiri, Persida; Crooks, Peter A.; Deo, Niranjan; Day, Cynthia S.; Caldwell, William S. Journal of Organic Chemistry, 2008 , vol. 73, # 9 p. 3497 - 3507

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Citation Number: 11

Abstract

In an attempt to generate nicotinic acetylcholine receptor (nAChR) ligands selective for the α4β2 and α7 subtype receptors we designed and synthesized constrained versions of anabasine, a naturally occurring nAChR ligand. 2-(Pyridin-3-yl)-1-azabicyclo [2.2. 2] octane, 2-(pyridin-3-yl)-1-azabicyclo [3.2. 2] nonane, and several of their derivatives have been synthesized in both an enantioselective and a racemic manner utilizing the same basic ...