The design and synthesis of inhibitors of imidazoleglycerol phosphate dehydratase as potential herbicides

…, R Barrett, JJ Swanborough, SE Russell…

Index: Cox; Hawkes; Bellini; Ellis; Barrett; Swanborough; Russell; Walker; Barnes; Knee; Lewis; Davies Pesticide Science, 1997 , vol. 50, # 4 p. 297 - 311

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Citation Number: 40

Abstract

Abstract The discovery and exploration of a new class of broad-spectrum post-emergent herbicides with a novel mode of action, namely the disruption of histidine biosynthesis via inhibition of imidazoleglycerol phosphate dehydratase (IGPD; EC 4.2. 1.19), are described. Clear structural similarities between the first member, produced during an attempt to produce analogues of glyphosate, and intermediates in histidine biosynthesis were noted. ...