There are several different routes to carboxamides. 1 In most of these reactions, a carboxylic acid is converted to a more reactive intermediate, eg, the acid chloride, which is then allowed to react with an amine. For practical reasons, it is preferable to form the reactive intermediate in situ. A carboxamide-forming reaction of the latter type has attracted our interest in the development of a reaction between carboxylic acids and primary or ...
