Il Farmaco

Synthesis of 4 (1H)-pyridinone derivatives and investigation of analgesic and antiinflammatory activities

G Öztürk, DD Erol, T Uzbay, MD Aytemir

Index: Oeztuerk, Guelcan; Erol, Dilek Demir; Uzbay, Tayfun; Aytemir, Mutlu Dilsiz Farmaco, 2001 , vol. 56, # 4 p. 251 - 256

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Citation Number: 38

Abstract

This paper describes recent results of a research program aimed at the synthesis and pharmacological evaluation of new 4 (1H)-pyridinone derivatives belonging to the 1, 3- disubstituted series (4–11). These compounds were structurally planned by applying the molecular hybridization strategy on previously described 1, 2-disubstituted-4 (1H)- pyridinone derivatives, considered as lead compounds, which present potent analgesic ...