Tetrahedron letters

A convenient one-pot synthesis of homoallylic halides and 1, 3-butadienes

KT Wong, YY Hung

Index: Wong, Ken-Tsung; Hung, Ying-Yueh Tetrahedron Letters, 2003 , vol. 44, # 43 p. 8033 - 8036

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Citation Number: 16

Abstract

An efficient one-pot synthetic pathway for the preparation of homoallylic halides by in situ generated MgBrCl-promoted ring opening of cyclopropylcarbinyl acetates has been established. An easily accessible one-pot synthetic protocol of 1, 3-butadienes by the elimination of hydrogen halides from the resulting homoallylic halides in the presence of an excess amount of strong base has also been developed.