Syntheses of amine derivatives of phencyclidine

PY Johnson, R Pan, JQ Wen…

Index: Johnson, Peter Y.; Pan, Robert; Wen, Jing Quan; Halfman, Clarke J. Journal of Organic Chemistry, 1981 , vol. 46, # 10 p. 2049 - 2054

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Citation Number: 20

Abstract

3-Aminophencyclidine (5) was synthesized by reduction of 3-nitrophencyclidine (3) using either H2 with Pd/C or Na2S in refluxing methanol. Attempts to isolate 4-aminophencyclidine (2), which we hoped to synthesize by hydrolysis of carbamate 15 which was isolated after reaction of amide 10 under Hofmann conditions employing bromine in CH30-/CH30H at-40" C, were unsuccessful. 4-Aminomethylphencyclidine (18) was synthesized by LAH ...