Tetrahedron: Asymmetry

A facile preparation of (±)-β-hydroxy nitriles and their enzymatic resolution with lipases

A Kamal, GBR Khanna

Index: Kamal, Ahmed; Khanna, G.B. Ramesh Tetrahedron Asymmetry, 2001 , vol. 12, # 3 p. 405 - 410

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Citation Number: 36

Abstract

A simple and efficient method for the preparation of racemic 4-aryloxy-3- hydroxybutanenitriles is described. Lipase mediated kinetic resolution in organic media was then utilised to effect enantioseparation. Lipases from different sources were screened in the resolution reaction using a number of organic solvents. Enantiomeric excesses of up to 99% were obtained by employing lipase from Pseudomonas cepacia in di-iso-propyl ether ...