New racemic 1, 4-disubstituted piperazines chemically named ethyl 2-[(4-pyrimidin-2yl- piperazine-1yl) carbonyl] C3-C5-alkanoates 1-7 were synthesized. The compounds were resolved into enantiomers on cellulose tris (4-methylbenzoate) and amylose tris (3, 5-