Asymmetric reduction of carbonyl compounds by yeast. IV. Preparation of optically active β-hydroxy sulfides, sulfoxides and sulfones

RL Crumbie, BS Deol, JE Nemorin, DD Ridley

Index: Crumbie,R.L. et al. Australian Journal of Chemistry, 1978 , vol. 31, p. 1965 - 1980

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Citation Number: 71

Abstract

Abstract Reduction of simple β-keto sulfides, β-keto sulfoxides and P-keto sulfones by an actively fermenting mutant of Saccharomyces cerevisiae proceeds readily and affords good yields of the corresponding optically active secondary alcohols. For example, 1-(benzylthio) propan-2-one gave optically pure (S)-(+)-1-(benzylthio) propan-2-ol and 1-(phenylsulfonyl) propan-2-one gave optically pure (S)-(+)-1-(phenylsulfonyl) propan-2-ol. In the reductions ...