e.g. Filippa Pettersson or Cancer Res. 75(6) , 1102-12, (2015) or 10.1002/anie.201600521
Reactions of 2-acyloxyisobutyryl halides with nucleosides. 7. Synthesis and biological evaluation of some 2, 2'-anhydro-1-(3', 5'-di-O-acyl-. beta.-D-arabinofuranosyl) …
EK Hamamura, M Prystasz…
Index: Hamamura,E.K. et al. Journal of Medicinal Chemistry, 1976 , vol. 19, p. 663 - 667
The direct acylation of 2, 2'-anhydro-l-(~-~-arabinofuranosyl) cytosine hydrochloride (cycloC) with a homologous series of saturated and unsaturated acyl chlorides in dimethylacetamide has been investigated. Such acylation reactions have made available a considerable number of 3', 5'-diesters of cycloC that have been examined for biological activities. The compounds all show cytotoxicity against HeLa cells in tissue culture and, with the ...
