Novel potassium channel openers: synthesis and pharmacological evaluation of new N-(substituted-3-pyridyl)-N'-alkylthioureas and related compounds

T Takemoto, M Eda, M Hihara, T Okada…

Index: Takemoto; Eda; Okada; Sakashita; Matzno; Gohda; Ebisu; Nakamura; Fukaya; Hihara; Eiraku; Yamanouchi; Yokoyama Journal of Medicinal Chemistry, 1994 , vol. 37, # 1 p. 18 - 25

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Citation Number: 18

Abstract

This report describes the synthesis and pharmacological evaluation of a series of novel potassium channel openers related to the pinacidil-type compounds. Thioureas, cyanoguanidines, and pyridine N-oxides were systematically evaluated for their effects on both the inhibition of spontaneous mechanical activity in rat portal vein (in vitro) and their antihypertensive activity (in vivo), and the structure-activity relationship for this series of ...

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Discovery of 6, 7-Dihydro-5 H-pyrrolo [2, 3-a] pyrimidines a...

[Katamreddy, Subba R.; Carpenter, Andrew J.; Ammala, Carina E.; Boros, Eric E.; Brashear, Ron L.; Briscoe, Celia P.; Bullard, Sarah R.; Caldwell, Richard D.; Conlee, Christopher R.; Croom, Dallas K.; Hart, Shane M.; Heyer, Dennis O.; Johnson, Paul R.; Kashatus, Jennifer A.; Minick, Doug J.; Peckham, Gregory E.; Ross, Sean A.; Roller, Shane G.; Samano, Vicente A.; Sauls, Howard R.; Tadepalli, Sarva M.; Thompson, James B.; Xu, Yun; Way, James M. Journal of Medicinal Chemistry, 2012 , vol. 55, # 24 p. 10972 - 10994]