Measurement of the rate of loss of 64Cu from the chelators used in the preparation of 64Cu- labeled proteins is critical to the development of effective 64Cu-labeled radiopharmaceuticals. Typically, however, this assessment has been made indirectly, by comparison of the relative uptake of the labeled proteins in the liver, or under non- physiological conditions such as hot 5M HCl. In the present study, we measured the rate ...
