Small-molecular inhibitors of Ca 2+-induced mitochondrial permeability transition (MPT) derived from muscle relaxant dantrolene

S Murasawa, K Iuchi, S Sato, T Noguchi-Yachide…

Index: Murasawa, Shinpei; Sato, Shinichi; Noguchi-Yachide, Tomomi; Hashimoto, Yuichi; Iuchi, Katsuya; Sodeoka, Mikiko; Dodo, Kosuke; Yokomatsu, Tsutomu; Aoyama, Hiroshi Bioorganic and Medicinal Chemistry, 2012 , vol. 20, # 21 p. 6384 - 6393,10

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Citation Number: 5

Abstract

A structure consisting of substituted hydantoin linked to a 5-(halophenyl) furan-2-yl group via an amide bond was identified as a promising scaffold for development of low-molecular- weight therapeutic agents to treat vascular dysfunction, including ischemia/reperfusion injury. Among the compounds synthesized, 5-(3, 5-dichlorophenyl)-N-{2, 4-dioxo-3-[(pyridin- 3-yl) methyl] imidazolidin-1-yl}-2-furamide (17) possessed the most potent inhibitory ...