Influence of Na+ on DNA reactions with aromatic epoxides and diol epoxides: evidence that DNA catalyzes the formation of benzo [a] pyrene and benz [a] anthracene …

H Fernando, CR Huang, A Milliman, L Shu…

Index: Fernando, Harshica; Huang, Chao-Ran; Milliman, Ann; Shu, Luchuan; LeBreton, Pierre R. Chemical Research in Toxicology, 1996 , vol. 9, # 8 p. 1391 - 1402

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Citation Number: 7

Abstract

Reactions of the benzo [a] pyrene (BP) and benz [a] anthracene (BA) metabolites,(±)-trans-7, 8-dihydroxy-anti-9, 10-epoxy-7, 8, 9, 10-tetrahydro-BP (BPDE),(±)-trans-3, 4-dihydroxy-anti- 1, 2-epoxy-1, 2, 3, 4-tetrahydro-BA (BADE),(±)-BP-4, 5-oxide (BPO), and (±)-BA-5, 6-oxide (BAO), were examined under pseudo-first-order conditions at varying Na+ (2.0-100 mM) and native, calf thymus DNA (ctDNA) concentrations. In 0.2 mM ctDNA and 2.0 mM Na+, at a ...