Synthesis and diuretic profile of 3-(3-amino-1, 2, 4-oxadiazol-5-yl)-5-chloro-2, 6-pyrazinediamine, an amiloride-type diuretic

JWH Watthey, M Desai, R Rutledge…

Index: Watthey, Jeffrey W. H.; Desai, Mahesh; Rutledge, Richard; Dotson, Ronald Journal of Medicinal Chemistry, 1980 , vol. 23, # 6 p. 690 - 692

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Citation Number: 29

Abstract

Journal of Medicinal Chemistry, 1980, Vol. 23, No. 6 691 dose, w/kg Po 5 b control 10 control 25 control 50 control 100 control oxadiazole analogue 3% of total Na', total K+, load a mequiv x 100 mequiv x 100 58.0 4.7 f 0.6 3.2 f 0.9 88.8" 33Be f 0.9 2. OC t 0.3 69.1 8.5 f 1.6 7.1 f 1.7 93.3 e 33.6 ef 2.8 1.8 ef 0.2 64.0 4.7 f 1.4 5.0 t 0.4 103.0 e 42.7 ef 4.4 1.9" i 0.2 64.9 3.0 i 0.8 5.3 f 1.1 100.4 d 41.6 ef 5.6 2.1 df 0.5 64.0 4.7 i 1.4 5.0 t 0.4 81.1 d 24.7 ef 2.7 1.1" ...