Synthesis and in vitro anti-hepatitis B virus activity of 6H-[1] benzothiopyrano [4, 3-b] quinolin-9-ols

…, Y Liu, W Li, Y Liu, D Zhang, P Zhang, P Gong

Index: Jia, Wei; Liu, Yajing; Li, Wei; Liu, Yan; Zhang, Dajun; Zhang, Peng; Gong, Ping Bioorganic and Medicinal Chemistry, 2009 , vol. 17, # 13 p. 4569 - 4574

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Citation Number: 20

Abstract

A series of novel 6H-[1] benzothiopyrano [4, 3-b] quinoline derivatives were prepared and evaluated for their anti-hepatitis B virus (HBV) activity and cytotoxicity in human hepatoblastoma-derived liver Hep-G2 cells. Compounds 10g, 10h, 10j, 10l and 10o were found to be potent anti-HBV compounds with IC50 values less than 50μM. The most promising compound was 10l, with an IC50 value of 14.7 μM and a SI value of 12.4. This ...