Synthesis of 2 ([Methyl-5-[(E)-2-aryl-1-ethenyl]-4-isoxazolyl] imino)-1, 3-thiazolan-4-ones and Their Mannich Bases

E Rajanarendar, P Ramesh, EK Rao…

Index: Rajanarendar; Ramesh; Rao, E. Kalyan; Reddy, A. Siva Rami Phosphorus, Sulfur and Silicon and the Related Elements, 2008 , vol. 183, # 10 p. 2555 - 2564

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Citation Number: 3

Abstract

Isoxazolyl chloroacetamides (2) were obtained from 4-amino-3-methyl-5-styrylisoxazoles (1) on reaction with chloroacetyl chloride. Cyclocondensation of 2 with NH4SCN yielded 2 ([- methyl-5-(E)-2-aryl-1-ethenyl]-4-isoxazolylimino)-1, 3-thiazolan-4-ones (3). Mannich reaction of 3 with formaldehyde and secondary amines gave isoxazolyl thiazolidinone Mannich bases (4 and 5).