Tetrahedron Letters

Catalytic enantioselective synthesis of azacycloalkenes via intermolecular rhodium carbenoid C–H insertion/ring-closing metathesis sequence

MC McMills, RJ Humes, OM Pavlyuk

Index: McMills, Mark C.; Humes, Ross J.; Pavlyuk, Oksana M. Tetrahedron Letters, 2012 , vol. 53, # 7 p. 849 - 851

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Citation Number: 10

Abstract

Enantiomerically enriched cyclopropanes and products of C–H insertion reactions were obtained in excellent combined yields and enantioselectivities as a consequence of rhodium- catalyzed decomposition of vinyl diazoacetate in the presence of tert-butoxycarbonyl-(Boc)- protected amines as trapping agents. A series of enantiomerically enriched six-to eight- membered nitrogen-containing heterocycles were subsequently prepared via ring-closing ...