In the early 1980s Höfle and co-workers reported the isolation of four novel polyketide derived antibiotics, myxopyronin A and B (1a and 1b) as well as corallopyronin A and B from the gliding bacteria Myxococcus fulvus Mx f50 and Corallococcus coralloides, respectively. 1, 2 This class of natural products which differ only by their length of the unsaturated side chain at the C3 position of the R-pyrone nucleus is virtually unexplored. The absolute ...
