Synlett

A novel one-pot synthesis of N-acylindoles from primary aromatic amides

M Abid, O De Paolis, B Toeroek

Index: Abid, Mohammed; De Paolis, Omar; Toeroek, Bela Synlett, 2008 , # 3 p. 410 - 412

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Citation Number: 19

Abstract

Abstract A novel one-pot synthesis of N-acylindoles via tandem cycloalkylation-annelation is described. This approach is based on the use of a strong solid-acid catalyst, montmorillonite K-10, and microwave irradiation under solvent-free conditions. The tandem cycloalkylation of amides and annelation of intermediate pyrroles were completed in minutes and provided good yields with high selectivities for the indoles. The safe, easy to handle catalyst, and ...