Synthesis and pharmacological examination of 1-(3-methoxy-4-methylphenyl)-2-aminopropane and 5-methoxy-6-methyl-2-aminoindan: Similarities to 3, 4-( …

MP Johnson, SP Frescas, R Oberlender…

Index: Johnson; Frescas; Oberlender; Nichols Journal of Medicinal Chemistry, 1991 , vol. 34, # 5 p. 1662 - 1668

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Citation Number: 49

Abstract

The racemate and the enantiomers of 1-(3-methoxy-4-methylphenyl)-2-aminopropane (6) and racemic bmeth-oxy-&methyl-2-aminoindan (11) were teated for stimulus generalization in the two-lever drug-discrimination paradigm. Both 6 and 11 were found to Substitute with high potency in 3, 4-(methylenedioxy) methamphetamine (1) and