Life sciences

Asymmetric synthesis of novel N-(1-phenyl-2, 3-dihydroxypropyl) arachidonylamides and evaluation of their anti-inflammatory activity

PV Kattamuri, R Salmonsen, C McQuain, S Burstein…

Index: Kattamuri, Padmanabha V.; Salmonsen, Rebecca; McQuain, Catherine; Burstein, Sumner; Sun, Hao; Li, Guigen Life Sciences, 2013 , vol. 92, # 8-9 p. 506 - 511

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Abstract

AIMS: To design and synthesize novel N-(1-phenyl-2, 3-dihydroxypropyl) arachidonylamides and evaluate their analgesic and anti-inflammatory potential. MAIN METHODS: The murine macrophage cell line RAW 264.7 has been widely used as a model for inflammatory responses in vitro. Our model consists of cultured monolayers of RAW 264.7 cells in which media concentrations of 15-deoxy-Δ13, 14-PGJ2 (PGJ) are measured ...